CHONDROCYTE MULTIPLICATION IN OSTEOARTHRITIC ARTICULAR CARTILAGE

Chondrocyte multiplication in osteoarthritic articular cartilage.

Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage.

OBJECTIVE To correlate the number of chondrocytes in healthy and osteoarthritic human articular cartilage with age, and to evaluate the influence of donor age on total proteoglycan synthesis. METHODS Chondrocytes were isolated from human articular cartilage derived from hip joints with and without osteoarthritic lesions. The cell number was normalised to cartilage sample wet weight. In additi...

Chondrocyte ultrastructure in adult human articular cartilage.

Age changes in the ultrastructure of articular chondrocytes have been studied in detail in mice (Silberberg, Silberberg, and Feir, 1964) and in rabbits (Davies, Barnett, Cochrane, and Palfrey, 1962; Barnett, Cochrane, and Palfrey, 1963). Less has been published concerning the influence of age on cellular ultrastructure in human articular cartilage. This is due partly to the scarcity of suitable...

The Expression of Signal Regulatory Protein-alpha in Normal and Osteoarthritic Human Articular Cartilage and Its Involvement in Chondrocyte Mechano-transduction Response

Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...

Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage

Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.   Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied.   Methods: Using immunohistochemistry and standard we...